Loads tensor of IL-2 mutein treatment responses. Tensor contains the signaling responses of eight different cell types to 13 IL-2 mutants. Dose-responses to 12 concentrations of muteins were collected at four time points for each mutant and cell type. Ligands include IL-2 mutants with modified receptor affinities, and in both mono- and bivalent formats. Useful for demonstrating execution and interpretation of non-negative CP decomposition.
Orcutt-Jahns, B., Emmel, P. C., Snyder, E. M., Posner, C., Carlson, S. M., & Meyer, A. S. (2021). Multivalency enhances the specificity of Fc-cytokine fusions. BioRxiv.